Serum and urine concentrations of morphine and morphine metabolites in patients with advanced cancer receiving continuous intravenous morphine: an observational study
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منابع مشابه
Serum and urine concentrations of morphine and morphine metabolites in patients with advanced cancer receiving continuous intravenous morphine: an observational study
BACKGROUND The feasibility and clinical implication of drug monitoring of morphine, morphine-6-glucuronide (M6G) and morphine-3-glucuronide (M3G) need further investigation. This study aimed to determine what predicts serum concentrations of morphine in cancer patients receiving continuously intravenous morphine, the relationships between serum concentration of morphine/its metabolites and urin...
متن کاملDay-to-day variations during clinical drug monitoring of morphine, morphine-3-glucuronide and morphine-6-glucuronide serum concentrations in cancer patients. A prospective observational study
BACKGROUND The feasibility of drug monitoring of serum concentrations of morphine, morphine-6-glucuronide (M6G) and morphine-3-glucuronide (M3G) during chronic morphine therapy is not established. One important factor relevant to drug monitoring is to what extent morphine, M6G and M3G serum concentrations fluctuate during stable morphine treatment. METHODS We included twenty-nine patients adm...
متن کاملDistribution of morphine and morphine metabolites in rat brain.
Misra et al. (1971) found that 1 h after a single subcutaneous injection of [N-Me-l4C1morphine into the rat, three radioactive compounds could be extracted from the cerebral cortex, namely free morphine, morphine 3-glucuronide and a ‘non-acid-hydrolysable’ conjugate. The regional and subcellular distribution of morphine and its metabolites in brain after subcutaneous injection has never been st...
متن کاملStudies on morphine disposition: influence of general anaesthesia on plasma concentrations of morphine and its metabolites.
The kinetics of morphine were studied during balanced anaesthesia in 10 patients undergoing lower abdominal or body surface surgery, and compared with those obtained in nine awake patients receiving morphine i.v. for the relief of chronic non-cancer pain. All patients received morphine sulfphate pentahydrate 10 mg i.v. over 30 s. Venous blood samples were collected for up to 180 min, and plasma...
متن کاملMorphine and morphine-glucuronide concentrations in plasma and CSF during long-term administration of oral morphine.
Concentrations of morphine, morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G) were measured by h.p.l.c. in plasma and cerebrospinal fluid (CSF) samples from 16 patients with cancer receiving oral (controlled-release) morphine. There was a close correlation between plasma and CSF morphine concentrations (r = 0.94, P = 0.0001) and both correlated with drug dosage (r = 0.61, P = 0.013 ...
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ژورنال
عنوان ژورنال: BMC Palliative Care
سال: 2015
ISSN: 1472-684X
DOI: 10.1186/s12904-015-0052-9